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Any of the bosses from resi 4 on hard mode. Impossible all of them.

Well the big fish was kind of easy but the other ones were really inpossible especially the right hand of Salazar.

Dark traya in kotor2

From what I've played, Sephiroth from Kingdom Hearts.

Bosses on Legend of Zelda games are hard because they are tough and you need to work out how to hurt them. On The Legend of Zelda: Ocarine of Time for Nintendo 64, the very last boss, Ganon was really hard; the fight just seemed to go for ever. However when they re-made the game for Gamecube, it did seem a lot easier. Anyway i think GANON is the hardest boss!

volcanboy above me, the LOZ bosses are easy as hell. I think the hardest would be the last boss on DMC3

ratchet and clank game the end boss is who the hardest i barely beat him even with the rhino.