Gordon Freeman All the way he is epic and DuKe Nukem cuz he is a bad @$$ cigar chomping mofo but his new game by gearbox sucks. I like the 3DO games better.
Oh jeez. I really can't pick just one, so here's as short a list as I care to make:
Auron - Final Fantasy X Minsc - Baldur's Gate Thrall, Medivh, and Cairne Bloodhoof - Warcraft John Marsten - Red Dead Redemption Raul Tejada - Fallout: New Vegas Mordin Solus, Garrus Vakarian, and Urdnot Wrex - Mass Effect Andrew Ryan - Bioshock Tyrael - Diablo